The MICAL2 Polyclonal Antibody (PACO10489) is a valuable tool for researchers studying MICAL2, a protein involved in intracellular signaling pathways and cytoskeletal dynamics. This antibody, raised in rabbits, has high reactivity with human samples and is validated for use in a variety of applications, including Western blotting. By binding specifically to MICAL2, this antibody allows for the detection and analysis of this protein in different cell types, making it ideal for studies in cell biology and neuroscience.MICAL2 is known for its role in actin cytoskeleton dynamics and has been implicated in processes such as cell migration, cell shape changes, and synaptic plasticity.
Understanding the function of MICAL2 is important for unraveling its contribution to various cellular processes and diseases. Researchers studying neurodegenerative disorders, cancer metastasis, and cell motility can benefit from using this antibody to investigate the role of MICAL2 in their experimental models.Overall, the MICAL2 Polyclonal Antibody (PACO10489) provides a reliable and specific tool for researchers interested in exploring the functions of MICAL2 in cellular biology and disease pathways. Its versatility and high reactivity make it a valuable asset for laboratories conducting research in the fields of neuroscience, cell biology, and cancer biology.
microtubule associated monoxygenase, calponin and LIM domain containing 2;MICAL2;DKFZp686H03148;DKFZp686H2469;KIAA0750;MICAL2PV1;MICAL2PV2 ;
UniProt Protein Function:
MICAL2: Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Belongs to the Mical family. 6 isoforms of the human protein are produced by alternative splicing.Protein type: EC 1.14.13.-; Adaptor/scaffoldChromosomal Location of Human Ortholog: 11p15.3Cellular Component: nucleusMolecular Function: actin binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygenBiological Process: actin filament depolymerization; cytoskeleton organization and biogenesis; heart development; heart looping; sulfur oxidation
