The MICAL1 Polyclonal Antibody (CAB15505) is a valuable tool for researchers studying MICAL1, a protein involved in various cellular processes, including cell migration and cytoskeletal dynamics. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the MICAL1 protein, this antibody allows for the detection and analysis of MICAL1 expression in different cell types, making it an essential component for studies in cell biology, cancer research, and neurobiology.MICAL1, a multidomain protein with diverse functions, is known for its role in regulating actin cytoskeleton dynamics and promoting cell migration.
Its involvement in processes such as axon guidance and cell adhesion makes it a key player in cellular function and development. Research into MICAL1 has implications for understanding neurodegenerative diseases, cancer metastasis, and other pathological conditions where cell migration and cytoskeletal rearrangement are dysregulated. By deciphering the mechanisms of MICAL1 activity, researchers can uncover new insights into these disease processes and potentially identify novel therapeutic targets.
Product Name:
MICAL1 Rabbit Polyclonal Antibody
SKU:
CAB15505
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 718-1067 of human MICAL1 (NP_073602.3).
This gene encodes an enzyme that oxidizes methionine residues on actin, thereby promoting depolymerization of actin filaments. This protein interacts with and regulates signalling by NEDD9/CAS-L (neural precursor cell expressed, developmentally down-regulated 9). Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
64780
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using MICAL1 Rabbit pAb (CAB15505) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
