The MICA Polyclonal Antibody (CAB1390) offered by Assay Genie is a vital tool for researchers interested in studying the MICA protein and its role in immune recognition and response. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it a reliable choice for Western blot experiments.MICA, a stress-induced ligand for the NKG2D receptor on natural killer (NK) cells and CD8+ T cells, plays a crucial role in immune surveillance and response against infected or malignant cells. By binding specifically to MICA, this polyclonal antibody enables the detection and analysis of MICA expression in various cell types, providing valuable insights into immune recognition mechanisms and their implications for diseases such as cancer and autoimmune disorders.
With its ability to target MICA, a key player in immune surveillance and anti-tumor immunity, the MICA Polyclonal Antibody (CAB1390) is an invaluable tool for researchers seeking to unravel the complexities of immune responses and develop novel therapeutic strategies in the fields of immunology and oncology.
Product Name:
MICA Rabbit Polyclonal Antibody
SKU:
CAB1390
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 24-307 of human MICA (NP_000238.1).
Cell membrane, Cytoplasm, Single-pass type I membrane protein.
Calculated MW:
43kDa
Observed MW:
43kDa
This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
100507436
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using MICA antibody (CAB1390) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
