MICA Rabbit Polyclonal Antibody (CAB1390)
- SKU:
- CAB1390
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
Product Name: | MICA Rabbit Polyclonal Antibody |
SKU: | CAB1390 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-307 of human MICA (NP_000238.1). |
Sequence: | EPHS LRYN LTVL SWDG SVQS GFLT EVHL DGQP FLRC DRQK CRAK PQGQ WAED VLGN KTWD RETR DLTG NGKD LRMT LAHI KDQK EGLH SLQE IRVC EIHE DNST RSSQ HFYY DGEL FLSQ NLET KEWT MPQS SRAQ TLAM NVRN FLKE DAMK TKTH YHAM HADC LQEL RRYL KSGV VLRR TVPP MVNV TRSE ASEG NITV TCRA SGFY PWNI TLSW RQDG VSLS HDTQ QWGD VLPD GNGT YQTW VATR ICQG EEQR FTCY MEHS GNHS THPV PSGK VLVL QSHW |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | MIC-A; PERB11.1; MICA |
Positive Sample: | MCF7,SW480,NCI-H460,HepG2,HeLa,Mouse kidney,Mouse ovary,Rat kidney |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasm, Single-pass type I membrane protein. |
Calculated MW: | 43kDa |
Observed MW: | 43kDa |
This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 100507436 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |