The MICA Polyclonal Antibody (CAB12622) is a valuable tool for researchers studying MICA, a cell surface protein involved in immune responses and cancer development. This antibody, raised in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By targeting the MICA protein, this antibody enables the detection and analysis of MICA expression in various cell types, making it ideal for studies in immunology and cancer research.MICA, also known as stress-induced MHC class I chain-related protein, is a key player in the immune response to stress and disease.
Its role in immune surveillance and activation of Natural Killer cells makes it a promising target for investigations into cancer immunotherapy and autoimmune disorders. Understanding the function of MICA can provide insights into the mechanisms of immune evasion by cancer cells and potential therapeutic strategies to enhance immune recognition of tumors.Overall, the MICA Polyclonal Antibody (CAB12622) offers researchers a reliable tool for studying the role of MICA in immune responses and cancer, advancing our understanding of the complex interplay between the immune system and disease progression.
Product Name:
MICA Rabbit Polyclonal Antibody
SKU:
CAB12622
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 24-307 of human MICA (NP_000238.1).
Cell membrane, Cytoplasm, Single-pass type I membrane protein.
Calculated MW:
43kDa
Observed MW:
50kDa
This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
100507436
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using MICA Antibody (CAB12622) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
