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MHC CLASS II, I-E Monoclonal Antibody [NYRmI-E] (CPAB0504)

SKU:
CPAB0504
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Universal
Host Species:
Mouse
Isotype:
IgG2a
Clone:
NYRmI-E
€660
Frequently bought together:

Description

system_update_alt Datasheet

MHC CLASS II, I-E Monoclonal Antibody [NYRmI-E] (CPAB0504)

The MHC Class II I-E Antibody (CPAB0504) is a vital tool for researchers studying the major histocompatibility complex (MHC) class II molecule I-E. This antibody, produced in rabbits, is highly specific and reactive with samples from various species, including human, mouse, and rat. It has been validated for use in multiple applications, including Western blot and immunohistochemistry, making it a versatile option for a range of research needs.The MHC class II molecule I-E plays a crucial role in antigen presentation to CD4+ T cells, contributing to the regulation of immune responses and the development of adaptive immunity. By targeting this specific molecule with the CPAB0504 antibody, researchers can accurately detect and analyze MHC class II I-E expression in different cell types and tissues.

This makes it an invaluable tool for studies in immunology, infectious diseases, and autoimmune disorders.By delving into the intricate mechanisms of MHC class II I-E function, researchers can gain insights into how the immune system identifies and responds to pathogens, as well as how dysregulation of this process can lead to diseases such as autoimmunity and cancer. The CPAB0504 antibody provides a reliable means of investigating these complex processes and advancing our understanding of immune system function.

Product Name:MHC CLASS II, I-E Antibody
Product Sku:CPAB0504
Size:500μg
Host Species:Mouse
Immunogen:Purified mouse LN B cells (C3H anti-C57Bl6).
Clone:NYRmI-E.
Reactivity:Other bodies
Applications:
Purification Method:Ion exchange column.
Isotype:IgG2a
Background:MHC Class II is consists of 2 membrane spanning proteins. Each of these proteins is roughly 30 kDa, and has of two Globular domains, Alpha-1, Alpha-2, Beta-1 and Beta-2. The two regions farthest away from the membrane are alpha-1 and beta-1. The two proteins link without Covalent Bonds. The MHC Class II protein mainly presents peptides, which have been digested from external sources. MHC Class II is normally only expressed by Antigen Presenting Cells (APC) which digest foreign protein. Within the RER the alpha and beta proteins of the molecule, associate with each other, while a third protein called the "invariant chain," is necessary for stabilizing the complex, without it, they will not associate. The MHC-invariant complex is then passed from the RER, into and out of, the Golgi body. It fuses with an Endocytic compartment, where an external protein has been sampled and degraded.
Synonyms:
Storage Buffer:Lyophilized: store at 4?C. After reconstitution, if not intended for use within a month, aliquot and store at -20?C.

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