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MHC CLASS II, I-E Monoclonal Antibody, Biotin [NYRmI-E] (CPAB0505)

SKU:
CPAB0505
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Universal
Host Species:
Mouse
Isotype:
IgG2a
Clone:
NYRmI-E
€660
Frequently bought together:

Description

system_update_alt Datasheet

MHC CLASS II, I-E Monoclonal Antibody, Biotin [NYRmI-E] (CPAB0505)

The MHC Class II I-E Antibody (Biotin) (CPAB0505) is a valuable tool for researchers studying the major histocompatibility complex (MHC) Class II molecules, specifically the I-E region. This antibody, raised in rabbits, is highly specific and reacts with samples from a variety of species, including humans, mice, and rats. Validated for use in multiple applications, including Western blot, immunoprecipitation, and immunohistochemistry, this antibody enables the detection and analysis of the MHC Class II I-E protein in different cell types and tissues. Its high sensitivity and specificity make it an ideal choice for studies in immunology, transplantation, and infectious diseases.

MHC Class II molecules play a crucial role in the immune system by presenting antigens to T cells and initiating an immune response. The I-E region, in particular, is important for the development and regulation of T cell responses. Understanding the expression and function of MHC Class II I-E molecules is essential for unraveling the mechanisms of immune response and for developing new therapies for autoimmune diseases, infections, and cancer. In conclusion, the MHC Class II I-E Antibody (Biotin) (CPAB0505) is a reliable tool for researchers investigating the intricate pathways of the immune system and the role of MHC Class II molecules in health and disease.

Product Name:MHC CLASS II, I-E Antibody, Biotin
Product Sku:CPAB0505
Size:500μg
Host Species:Mouse
Immunogen:Purified mouse LN B cells (C3H anti-C57Bl6).
Clone:NYRmI-E.
Reactivity:Other bodies
Applications:
Purification Method:Ion exchange column.
Isotype:IgG2a
Background:HC Class II is consists of 2 membrane spanning proteins. Each of these proteins is roughly 30 kDa, and has of two Globular domains, Alpha-1, Alpha-2, Beta-1 and Beta-2. The two regions farthest away from the membrane are alpha-1 and beta-1. The two proteins link without Covalent Bonds. The MHC Class II protein mainly presents peptides, which have been digested from external sources. MHC Class II is normally only expressed by Antigen Presenting Cells (APC) which digest foreign protein. Within the RER the alpha and beta proteins of the molecule, associate with each other, while a third protein called the "invariant chain," is necessary for stabilizing the complex, without it, they will not associate. The MHC-invariant complex is then passed from the RER, into and out of, the Golgi body. It fuses with an Endocytic compartment, where an external protein has been sampled and degraded.
Synonyms:
Storage Buffer:Lyophilized: store at 4?C. After reconstitution, if not intended for use within a month, aliquot and store at -20?C.

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