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MHC Class II, I-A Monoclonal Antibody, FITC [NYRmI-A] (CPAB0502)

SKU:
CPAB0502
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Universal
Host Species:
Mouse
Isotype:
IgG2a
Clone:
NYRmI-A
€660
Frequently bought together:

Description

system_update_alt Datasheet

MHC Class II, I-A Monoclonal Antibody, FITC [NYRmI-A] (CPAB0502)

The MHC Class II I-A Antibody (FITC) (CPAB0502) is a valuable tool for research involving major histocompatibility complex class II, specifically the I-A isoform. This antibody, derived from rabbits, is highly specific for human samples and is validated for use in immunofluorescence applications. By binding to the MHC Class II I-A protein, this antibody allows for the visualization and analysis of this important molecule in various cell types, making it an ideal choice for studies in immunology and disease research.The MHC Class II I-A molecule plays a crucial role in presenting antigens to T cells, thereby initiating immune responses.

Understanding the expression and function of MHC Class II I-A in different cell populations is essential for unraveling the complexities of the immune system and developing targeted therapies for various diseases. This antibody facilitates the investigation of MHC Class II I-A in the context of autoimmune disorders, infectious diseases, and transplantation research, providing valuable insights into immune regulation and disease pathogenesis.

Product Name:MHC Class II, I-A Antibody, FITC
Product Sku:CPAB0502
Size:500μg
Host Species:Mouse
Immunogen:Purified mouse LN B cells (C3H anti-C57Bl6).
Clone:NYRmI-A.
Reactivity:Other bodies
Applications:
Purification Method:Ion exchange column.
Isotype:IgG2a
Background:MHC Class II is consists of 2 membrane spanning proteins. Each of these proteins is roughly 30 kDa, and has of two Globular domains, Alpha-1, Alpha-2, Beta-1 and Beta-2. The two regions farthest away from the membrane are alpha-1 and beta-1. The two proteins link without Covalent Bonds. The MHC Class II protein mainly presents peptides, which have been digested from external sources. MHC Class II is normally only expressed by Antigen Presenting Cells (APC) which digest foreign protein. Within the RER the alpha and beta proteins of the molecule, associate with each other, while a third protein called the "invariant chain," is necessary for stabilizing the complex, without it, they will not associate. The MHC-invariant complex is then passed from the RER, into and out of, the Golgi body. It fuses with an Endocytic compartment, where an external protein has been sampled and degraded.
Synonyms:
Storage Buffer:Lyophilized: store at 4°C. After reconstitution, if not intended for use within a month, aliquot and store at -20°C.

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