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MHC Class II, I-A Monoclonal Antibody, Biotin [NYRmI-A] (CPAB0501)

SKU:
CPAB0501
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Universal
Host Species:
Mouse
Isotype:
IgG2a
Clone:
NYRmI-A
€660
Frequently bought together:

Description

system_update_alt Datasheet

MHC Class II, I-A Monoclonal Antibody, Biotin [NYRmI-A] (CPAB0501)

The MHC Class II (I-A) Antibody (Biotin) (CPAB0501) is a key tool for researchers studying the major histocompatibility complex class II (MHC II) molecules. This antibody, produced in rabbits, specifically binds to the MHC Class II (I-A) protein, which is essential for presenting antigens to T cells and regulating immune responses.With its biotin conjugation, this antibody is suitable for various applications, including immunohistochemistry, flow cytometry, and ELISA assays. It is highly reactive with human samples and has been validated for use in different experimental settings.MHC Class II molecules are crucial for initiating immune responses against pathogens and foreign substances.

By targeting MHC Class II (I-A) with this antibody, researchers can better understand the antigen presentation process and how it influences immune cell activation and function.Overall, the MHC Class II (I-A) Antibody (Biotin) (CPAB0501) is a valuable tool for investigating the role of MHC II molecules in immune system function, autoimmune diseases, and immunotherapy research. Its specificity and versatility make it a valuable asset for immunologists and researchers in the field.

Product Name:MHC Class II, I-A Antibody, Biotin
Product Sku:CPAB0501
Size:500μg
Host Species:Mouse
Immunogen:Purified mouse LN B cells (C3H anti-C57Bl6).
Clone:NYRmI-A.
Reactivity:Other bodies
Applications:
Purification Method:Ion exchange column.
Isotype:IgG2a
Background:MHC Class II is consists of 2 membrane spanning proteins. Each of these proteins is roughly 30 kDa, and has of two Globular domains, Alpha-1, Alpha-2, Beta-1 and Beta-2. The two regions farthest away from the membrane are alpha-1 and beta-1. The two proteins link without Covalent Bonds. The MHC Class II protein mainly presents peptides, which have been digested from external sources. MHC Class II is normally only expressed by Antigen Presenting Cells (APC) which digest foreign protein. Within the RER the alpha and beta proteins of the molecule, associate with each other, while a third protein called the "invariant chain," is necessary for stabilizing the complex, without it, they will not associate. The MHC-invariant complex is then passed from the RER, into and out of, the Golgi body. It fuses with an Endocytic compartment, where an external protein has been sampled and degraded.
Synonyms:
Storage Buffer:Lyophilized: store at 4°C. After reconstitution, if not intended for use within a month, aliquot and store at -20°C.

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