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MHC Class I, H-2K Monoclonal Antibody, Biotin [NYRmH-2K] (CPAB0498)

SKU:
CPAB0498
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Universal
Host Species:
Mouse
Isotype:
IgG2b
Clone:
NYRmH-2K
€660
Frequently bought together:

Description

system_update_alt Datasheet

MHC Class I, H-2K Monoclonal Antibody, Biotin [NYRmH-2K] (CPAB0498)

The MHC Class I H-2K Antibody (BIOTIN) (CPAB0498) is a valuable tool for researchers studying the immune system and antigen presentation. This antibody, raised in rabbits, is specifically designed to target the H-2K protein, an important component of the major histocompatibility complex (MHC) class I molecules. It is validated for use in various applications, including flow cytometry and immunohistochemistry, making it versatile for different experimental needs.The H-2K protein plays a crucial role in presenting antigens to cytotoxic T cells, triggering immune responses against infected or abnormal cells. By targeting H-2K with this antibody, researchers can study the interactions between antigens and T cells, providing insights into immune surveillance and response mechanisms.

This antibody is particularly useful for investigating the immune response to infections, cancer, and autoimmune disorders where MHC class I molecules are involved.Overall, the MHC Class I H-2K Antibody (BIOTIN) (CPAB0498) is a valuable tool for understanding the immune system and its role in various diseases. Its high reactivity with mouse samples and reliability in different experimental techniques make it a key component in immunology research.

Product Name:MHC Class I, H-2K Antibody, Biotin
Product Sku:CPAB0498
Size:500μg
Host Species:Mouse
Immunogen:Purified mouse LN cells (C57Bl/6 anti-BALB/c).
Clone:NYRmH-2K.
Reactivity:Other bodies
Applications:
Purification Method:Ion exchange column.
Isotype:IgG2b
Background:MHC Class I is a membrane spanning molecule consisting of 2 proteins. MHC Class I is just about 350 amino acids in length, with roughly 75 amino acids at the carboxylic end comprising the transmembrane and cytoplasmic portions. The remaining 270 amino acids, are divided into three globular domains labeled Alpha-1, Alpha-2 and Alpha-3 prime, with Alpha-1 being closest to the amino terminus and Alpha-3 closest to the membrane. The second portion of the molecule is a small globular protein called Beta-2 Microglobulin. It links primarily with the Alpha-3 prime domain and is essential for MHC stability. The MHC ability to show a vast range of antigenic peptides for T cell recognition needs a compromise between broad specificity and high affinity. Both MHC class I and MHC class II show an exceptional structure while the peptide main chain is tightly bound and peptide side chains show less restrictive interactions. It is primarily the peptide side-chain contacts and conformational variability that ensures that the peptide-MHC complex presents an antigenically unique surface to T cell receptors.
Synonyms:
Storage Buffer:Lyophilized: store at 4°C. After reconstitution, if not intended for use within a month, aliquot and store at -20°C.

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