The Matrix Gla Protein Polyclonal Antibody (CAB5439) is a valuable tool for researchers studying Matrix Gla Protein (MGP), a key regulator of tissue calcification and cardiovascular health. Raised in rabbits, this antibody demonstrates high reactivity with human samples and is validated for use in various applications including Western blotting.Matrix Gla Protein is known for its role in preventing pathological calcification of soft tissues, particularly in blood vessels. Dysregulation of MGP expression has been linked to conditions such as arterial calcification, atherosclerosis, and cardiovascular disease. By targeting MGP, researchers can investigate its function in maintaining vascular health and explore potential therapeutic interventions for cardiovascular disorders.
This polyclonal antibody binds specifically to Matrix Gla Protein, allowing for precise detection and analysis in cell and tissue samples. Its versatility and reliability make it an essential tool for studies in cardiovascular biology, vascular biology, and related fields. By studying the mechanisms of MGP action, researchers can gain insight into the pathophysiology of cardiovascular diseases and develop targeted treatments to improve patient outcomes.
Product Name:
MGP Rabbit Polyclonal Antibody
SKU:
CAB5439
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-103 of human MGP (NP_000891.2).
This gene encodes a member of the osteocalcin/matrix Gla family of proteins. The encoded vitamin K-dependent protein is secreted by chondrocytes and vascular smooth muscle cells, and functions as a physiological inhibitor of ectopic tissue calcification. Carboxylation status of the encoded protein is associated with calcification of the vasculature in human patients with cardiovascular disease and calcification of the synovial membranes in osteoarthritis patients. Mutations in this gene cause Keutel syndrome in human patients, which is characterized by abnormal cartilage calcification, peripheral pulmonary stenosis and facial hypoplasia.
Purification Method:
Affinity purification
Gene ID:
4256
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from SH-SY5Y cells, using MGP Rabbit pAb (CAB5439) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
