MGMT Rabbit Monoclonal Antibody (CAB11151)
- SKU:
- CAB11151
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | MGMT Rabbit Monoclonal Antibody |
SKU: | CAB11151 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 108-207 of human MGMT (NP_002403.3). |
Sequence: | FGEV ISYQ QLAA LAGN PKAA RAVG GAMR GNPV PILI PCHR VVCS SGAV GNYS GGLA VKEW LLAH EGHR LGKP GLGG SSGL AGAW LKGA GATS GSPP AGRN |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | MGMT; O-6-methylguanine-DNA methyltransferase |
Positive Sample: | HeLa,MCF7,Jurkat |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus |
Calculated MW: | 22kDa |
Observed MW: | 22kDa |
Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma.
Purification Method: | Affinity purification |
Gene ID: | 4255 |
Clone Number: | ARC0529 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3. |