MGMT Rabbit Polyclonal Antibody (CAB0052)
- SKU:
- CAB0052
- Product Type:
- Antibody
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | MGMT Rabbit Polyclonal Antibody |
SKU: | CAB0052 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-207 of human MGMT (NP_002403.2). |
Sequence: | MLGQ PAPL ERFA SRRP QVLA VRTV CDLV LGKM DKDC EMKR TTLD SPLG KLEL SGCE QGLH EIKL LGKG TSAA DAVE VPAP AAVL GGPE PLMQ CTAW LNAY FHQP EAIE EFPV PALH HPVF QQES FTRQ VLWK LLKV VKFG EVIS YQQL AALA GNPK AARA VGGA MRGN PVPI LIPC HRVV CSSG AVGN YSGG LAVK EWLL AHEG HRL |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | MGMT |
Positive Sample: | Jurkat |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 22kDa |
Observed MW: | 22kDa |
Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma.
Purification Method: | Affinity purification |
Gene ID: | 4255 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |