The MFNG Polyclonal Antibody (PAC004325) offered by Assay Genie is a reliable tool for studying MFNG, a protein involved in the regulation of Notch signaling pathways. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot assays. By specifically binding to MFNG, researchers can detect and analyze this protein in a variety of cell types, making it a valuable asset for investigations in molecular biology and developmental biology.MFNG, also known as Fringe, plays a crucial role in modulating Notch receptor interactions and subsequent signaling cascades. Dysregulation of Notch signaling has been implicated in various diseases, including cancer and developmental disorders, highlighting the importance of studying proteins like MFNG.
By elucidating the functions of MFNG, researchers can gain insights into potential therapeutic targets for diseases associated with aberrant Notch signaling pathways.Overall, the MFNG Polyclonal Antibody from Assay Genie provides researchers with a reliable tool for studying the role of MFNG in cellular processes and disease mechanisms. Its specificity and sensitivity make it an ideal choice for a wide range of research applications in the fields of molecular biology, developmental biology, and disease pathology.
Antibody Name:
MFNG Antibody
Antibody SKU:
PACO04325
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the Internal region of human Manic Fringe.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
MFNG: Glycosyltransferase involved in the elongation of O- linked ligands to activate Notch signaling. Possesses fucose- specific beta-1,3-N-acetylglucosaminyltransferase activity. Belongs to the glycosyltransferase 31 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Transferase; Membrane protein, integral; EC 2.4.1.222Chromosomal Location of Human Ortholog: 22q12Cellular Component: extracellular space; integral to Golgi membraneMolecular Function: metal ion binding; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activityBiological Process: positive regulation of protein binding; metabolic process; pattern specification process; positive regulation of Notch signaling pathway
UniProt Protein Details:
NCBI Summary:
This gene is a member of the glycosyltransferase 31 gene family. Members of this gene family, which also includes the LFNG (GeneID: 3955) and RFNG (GeneID: 5986) genes, encode evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, these proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. The protein encoded by this gene may control Notch signaling in claudin-low breast cancer. [provided by RefSeq, May 2018]
