The MFN2 Polyclonal Antibody (CAB13606) is a high-quality research tool designed for investigations involving MFN2, a protein implicated in mitochondrial fusion and function. This antibody, generated in rabbits, has been shown to be highly specific for human samples and is validated for use in Western blot applications. By binding to the MFN2 protein, researchers can detect and analyze its expression in a variety of cell types, making it an excellent choice for studies in cell biology and mitochondrial research.MFN2, also known as Mitofusin-2, is a key player in mitochondrial dynamics and function, essential for maintaining proper energy production and cellular health.
Dysregulation of MFN2 has been linked to various diseases, including neurodegenerative disorders and metabolic conditions. Studying the role of MFN2 in these contexts can provide valuable insights into disease mechanisms and potential therapeutic targets.Overall, the MFN2 Polyclonal Antibody is a valuable tool for researchers interested in exploring the functions of MFN2 in health and disease. Its specificity and reliability make it a trusted reagent for studies aimed at understanding mitochondrial dynamics and their impact on cellular physiology.
Product Name:
Mitofusin 2 Rabbit Polyclonal Antibody
SKU:
CAB13606
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 70-260 of mouse Mitofusin 2 (NP_573464.2).
Predicted to enable several functions, including GTP binding activity; GTPase activity; and enzyme binding activity. Involved in mitochondrial fusion; parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization; and positive regulation of cold-induced thermogenesis. Acts upstream of or within blastocyst formation and camera-type eye morphogenesis. Located in microtubule cytoskeleton and mitochondrion. Is expressed in several structures, including brain; early conceptus; eye; heart; and oocyte. Used to study Charcot-Marie-Tooth disease type 2A2A. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease; Charcot-Marie-Tooth disease type 2A2A; Charcot-Marie-Tooth disease type 2A2B; and Charcot-Marie-Tooth disease type 6. Orthologous to human MFN2 (mitofusin 2).
Purification Method:
Affinity purification
Gene ID:
170731
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using Mitofusin 2 Rabbit pAb (CAB13606) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
