The MFGE8 Polyclonal Antibody (CAB12322) is a key tool for researchers studying MFGE8, a protein involved in various cellular processes such as phagocytosis and tissue remodeling. This antibody, generated in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the MFGE8 protein, researchers can easily detect and analyze its expression in a variety of cell types, making it a valuable asset for studies in immunology, cell biology, and cancer research.MFGE8, also known as lactadherin, plays a critical role in mediating interactions between apoptotic cells and phagocytes, promoting immune tolerance and resolution of inflammation.
Its involvement in processes like cell adhesion and migration also positions it as a potential target for therapeutic interventions in diseases such as cancer, autoimmune disorders, and cardiovascular diseases. By understanding the function of MFGE8, researchers can uncover new insights into disease mechanisms and potentially develop novel treatment strategies.
Product Name:
MFGE8 Rabbit Polyclonal Antibody
SKU:
CAB12322
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human MFGE8 (NP_005919.2).
This gene encodes a preproprotein that is proteolytically processed to form multiple protein products. The major encoded protein product, lactadherin, is a membrane glycoprotein that promotes phagocytosis of apoptotic cells. This protein has also been implicated in wound healing, autoimmune disease, and cancer. Lactadherin can be further processed to form a smaller cleavage product, medin, which comprises the major protein component of aortic medial amyloid (AMA). Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
4240
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using MFGE8 Rabbit pAb (CAB12322) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
