The MFF Polyclonal Antibody (CAB12392) is specifically designed for research involving MFF, a protein known for its role in mitochondrial fission and cell death pathways. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the MFF protein, this antibody enables accurate detection and analysis in a variety of cell types, making it a valuable tool for studies in cell biology and mitochondrial dynamics.MFF, also known as mitochondrial fission factor, is crucial for maintaining mitochondrial integrity and function by regulating the division of mitochondria.
Dysregulation of MFF has been implicated in various human diseases, including neurodegenerative disorders and cancer. Studying the mechanisms by which MFF modulates mitochondrial fission and cell death pathways is essential for understanding its role in disease pathogenesis and developing targeted therapies.Overall, the MFF Polyclonal Antibody (CAB12392) is a powerful research tool for investigating the function of MFF in mitochondrial dynamics and cell homeostasis, with potential implications for the development of novel therapeutic strategies.
Product Name:
MFF Rabbit Polyclonal Antibody
SKU:
CAB12392
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 15-170 of human MFF (NP_001263990.1).
Cytoplasmic vesicle, Mitochondrion outer membrane, Peroxisome, Single-pass type IV membrane protein, secretory vesicle, synaptic vesicle.
Calculated MW:
38kDa
Observed MW:
38kDa
This is a nuclear gene encoding a protein that functions in mitochondrial and peroxisomal fission. The encoded protein recruits dynamin-1-like protein (DNM1L) to mitochondria. There are multiple pseudogenes for this gene on chromosomes 1, 5, and X. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
56947
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from LO2 cells, using MFF Rabbit pAb (CAB12392) at 1:3000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 90s.
