The Mettl3 Polyclonal Antibody (CAB8370) is a valuable tool for research focused on Mettl3, an RNA methyltransferase involved in the regulation of gene expression. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the Mettl3 protein, this antibody enables the detection and analysis of Mettl3 in a variety of cell types, making it well-suited for investigations in molecular biology and cancer research.Mettl3 is a key player in the process of mRNA methylation, which has been linked to various cellular functions including RNA stability, translation efficiency, and protein synthesis.
Dysregulation of Mettl3 has been implicated in the development and progression of cancer, as well as other diseases involving aberrant gene expression. By studying the role of Mettl3 using this antibody, researchers can gain insights into the molecular mechanisms underlying these pathologies and potentially identify new therapeutic targets for intervention.
Product Name:
METTL3 Rabbit Polyclonal Antibody
SKU:
CAB8370
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-156 of human METTL3 (NP_062826.2).
This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine.
Purification Method:
Affinity purification
Gene ID:
56339
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from NIH/3T3 cells, using METTL3 Rabbit pAb (CAB8370) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
