The METTL3 Polyclonal Antibody is a valuable tool for researchers studying METTL3, an essential component of the m6A methyltransferase complex involved in the regulation of mRNA metabolism and translation. This antibody, generated in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the METTL3 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for investigations in the fields of RNA biology and gene expression regulation.
METTL3 is a key player in the dynamic regulation of mRNA methylation, influencing processes such as RNA splicing, stability, and translation efficiency. Dysregulation of METTL3 has been implicated in various diseases, including cancer and neurological disorders, highlighting its importance as a potential therapeutic target. By understanding the function and activity of METTL3, researchers can uncover new insights into cellular processes and potentially develop targeted treatments for multiple health conditions.
Product Name:
METTL3 Polyclonal Antibody
SKU:
CAB21572
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-156 of human METTL3 (NP_062826.2).
This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine.
Purification Method:
Affinity purification
Gene ID:
56339
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using METTL3 Rabbit pAb (CAB21572) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 20s.
