The Mettl14 Polyclonal Antibody (CAB8530) is a valuable tool for researchers studying Mettl14, an essential component of the m6A methyltransferase complex involved in regulating mRNA stability and gene expression. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to Mettl14 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for studies in molecular biology and RNA epigenetics.Mettl14 is a key player in the dynamic process of RNA modification known as m6A methylation, which has been linked to a wide range of biological processes including cellular differentiation, development, and disease.
Dysregulation of m6A modification has been implicated in various pathologies such as cancer, neurological disorders, and metabolic diseases. Understanding the role of Mettl14 in m6A methylation is essential for unraveling the complex mechanisms underlying these conditions and may lead to the development of novel therapeutic strategies.Overall, the Mettl14 Polyclonal Antibody is a valuable tool for researchers seeking to investigate the molecular mechanisms governing gene expression and RNA processing, with potential implications for a wide range of biological and disease processes.
Product Name:
METTL14 Rabbit Polyclonal Antibody
SKU:
CAB8530
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human METTL14 (NP_066012.1).
Enables mRNA binding activity. Contributes to mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity. Involved in mRNA metabolic process; negative regulation of hematopoietic progenitor cell differentiation; and positive regulation of translation. Located in nucleoplasm. Part of RNA N6-methyladenosine methyltransferase complex.
Purification Method:
Affinity purification
Gene ID:
57721
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using METTL14 Rabbit pAb (CAB8530) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
