METRNL Antibody (PACO36574)
- SKU:
- PACO36574
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
METRNL Antibody (PACO36574)
The METRNL Polyclonal Antibody (PAC036574) is a crucial tool for researchers studying METRNL, a member of the Meteorin-like family of proteins with immunoregulatory functions. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in various applications including Western blotting.METRNL, also known as Meteorin-like protein, plays a pivotal role in immune regulation by modulating inflammatory responses and promoting tissue repair. Its involvement in various physiological processes such as metabolism, adipogenesis, and cardiac function makes it a promising target for studies in immunology, metabolic disorders, and cardiovascular diseases.
By using the METRNL Polyclonal Antibody, researchers can detect and analyze METRNL protein expression in different cell types, helping to advance our understanding of its functions in health and disease. This antibody is a valuable tool for investigating the potential therapeutic implications of targeting METRNL in various pathologies, paving the way for innovative treatment strategies.
| Antibody Name: | METRNL Antibody (PACO36574) |
| Antibody SKU: | PACO36574 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant Human Meteorin-like protein (46-311AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: METRNL antibody at 2µg/ml. Lane 1: Mouse small intestine tissue. Lane 2: Mouse kidney tissue. Lane 3: Rat gonadal tissue. Lane 4: Mouse brain tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 35, 26 kDa. Observed band size: 35 kDa. |
 | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO36574 at dilution of 1:100. |
| Background: | Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures. |
| Synonyms: | Meteorin-like protein (Subfatin), METRNL |
| UniProt Protein Function: | METRNL: Belongs to the meteorin family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 17q25.3 Cellular Component: extracellular space Molecular Function:hormone activity Biological Process: brown fat cell differentiation; fat cell differentiation; negative regulation of inflammatory response; response to cold; response to muscle activity |
| UniProt Code: | Q641Q3 |
| NCBI GenInfo Identifier: | 52345387 |
| NCBI Gene ID: | 284207 |
| NCBI Accession: | NP_001004431.1 |
| UniProt Secondary Accession: | Q641Q3,Q86VM0, B3KSJ5, |
| UniProt Related Accession: | Q641Q3 |
| Molecular Weight: | 31.96kD |
| NCBI Full Name: | meteorin-like protein |
| NCBI Synonym Full Names: | meteorin like, glial cell differentiation regulator |
| NCBI Official Symbol: | METRNLÂ Â |
| NCBI Protein Information: | meteorin-like protein |
| UniProt Protein Name: | Meteorin-like protein |
| UniProt Synonym Protein Names: | Subfatin |
| Protein Family: | Meteorin |
| UniProt Gene Name: | METRNLÂ Â |
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