METAP2 Rabbit Polyclonal Antibody (CAB5962)
- SKU:
- CAB5962
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | METAP2 Rabbit Polyclonal Antibody |
SKU: | CAB5962 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human METAP2 (NP_006829.1). |
Sequence: | MAGV EEVA ASGS HLNG DLDP DDRE EGAA STAE EAAK KKRR KKKK SKGP SAAG EQEP DKES GASV DEVA RQLE RSAL EDKE RDED DEDG DGDG DGAT GKKK KKKK KKRG PKVQ TDPP SVPI CDLY PNGV FPKG QECE YPPT QDGR TAAW RTTS EEKK ALDQ ASEE IWND FREA AEAH RQVR KYVM SWIK PGMT MIEI CEKL EDCS RKLI KENG LNAG LAFP |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:200 - 1:2000 |
Synonyms: | MAP2; MNPEP; p67eIF2; METAP2 |
Positive Sample: | SH-SY5Y,HL-60,Mouse liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm. |
Calculated MW: | 53kDa |
Observed MW: | 60kDa |
The protein encoded by this gene is a member of the methionyl aminopeptidase family. The encoded protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent proteins. Increased expression of this gene is associated with various forms of cancer, and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. Inhibitors of this gene have also been shown to be effective for the treatment of obesity. A pseudogene of this gene is located on chromosome 2. Several transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 10988 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |