MET Rabbit Polyclonal Antibody (CAB17366)
- SKU:
- CAB17366
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | MET Rabbit Polyclonal Antibody |
SKU: | CAB17366 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 518-840 of human MET (NP_000236.2). |
Sequence: | LGCR HFQS CSQC LSAP PFVQ CGWC HDKC VRSE ECLS GTWT QQIC LPAI YKVF PNSA PLEG GTRL TICG WDFG FRRN NKFD LKKT RVLL GNES CTLT LSES TMNT LKCT VGPA MNKH FNMS IIIS NGHG TTQY STFS YVDP VITS ISPK YGPM AGGT LLTL TGNY LNSG NSRH ISIG GKTC TLKS VSNS ILEC YTPA QTIS TEFA VKLK IDLA NRET SIFS YRED PIVY EIHP TKSF ISGG STIT GVGK NLNS VSVP RMVI NVHE AGRN FTVA CQHR SNSE IICC TTPS LQQL NLQL PLKT KAFF MLDG ILSK YFDL IYVH NPV |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 |
Synonyms: | DA11; HGFR; AUTS9; RCCP2; c-Met; DFNB97; MET |
Positive Sample: | Mouse liver,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Membrane, Secreted, Single-pass type I membrane protein. |
Calculated MW: | 156kDa |
Observed MW: | 170kDa |
This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers.
Purification Method: | Affinity purification |
Gene ID: | 4233 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |