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MET Rabbit Polyclonal Antibody (CAB0040)

SKU:
CAB0040
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:MET Rabbit Polyclonal Antibody
SKU:CAB0040
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 960-1161 of human MET (NP_000236.2).
Sequence:QIKD LGSE LVRY DARV HTPH LDRL VSAR SVSP TTEM VSNE SVDY RATF PEDQ FPNS SQNG SCRQ VQYP LTDM SPIL TSGD SDIS SPLL QNTV HIDL SALN PELV QAVQ HVVI GPSS LIVH FNEV IGRG HFGC VYHG TLLD NDGK KIHC AVKS LNRI TDIG EVSQ FLTE GIIM KDFS HPNV LSLL GICL RSEG SPLV VLPY MK
Tested Applications:WB ELISA
Recommended Dilution:WB,1:100 - 1:500
Synonyms:DA11; HGFR; AUTS9; RCCP2; c-Met; DFNB97; MET
Positive Sample:Rat kidney
Conjugate:Unconjugated
Cellular Localization:Membrane, Secreted, Single-pass type I membrane protein.
Calculated MW:156kDa
Observed MW:140kDa/170kDa

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers.

Purification Method:Affinity purification
Gene ID:4233
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of Rat kidney, using MET antibody (CAB0040) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.

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