The Mesothelin Polyclonal Antibody (CAB6183) is a valuable tool for researchers studying mesothelin, a cell surface glycoprotein that is overexpressed in various cancers, particularly mesothelioma. This antibody, produced in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications. It specifically binds to the mesothelin protein, enabling accurate detection and analysis in a variety of cell types.Mesothelin is a promising biomarker and potential target for cancer therapy, making this antibody ideal for studies in oncology and tumor biology.
Its role in promoting cancer cell proliferation and metastasis, as well as its association with drug resistance, make understanding mesothelin crucial for developing effective treatments for mesothelioma and other mesothelin-expressing cancers.By using the Mesothelin Polyclonal Antibody (CAB6183), researchers can further explore the function and regulation of mesothelin in cancer development and progression, ultimately leading to advancements in personalized medicine and targeted therapies for patients with mesothelin-positive tumors.
Product Name:
MSLN Rabbit Polyclonal Antibody
SKU:
CAB6183
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 296-606 of human Mesothelin (NP_037536.2).
This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
Purification Method:
Affinity purification
Gene ID:
10232
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of OVCAR3 cells, using (CAB6183) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
