MERTK/TYRO3 (Ab-753) Antibody (PACO21647)
- SKU:
- PACO21647
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
MERTK/TYRO3 (Ab-753) Antibody (PACO21647)
The MERTK & TYRO3 Polyclonal Antibody (AB-753) is a valuable tool for researchers studying the MERTK and TYRO3 receptors, which play crucial roles in immune regulation and signaling pathways. This rabbit-derived antibody is highly reactive with human samples and is validated for use in applications such as Western blot and immunohistochemistry.MERTK and TYRO3 are receptor tyrosine kinases that are involved in the regulation of immune responses, phagocytosis, and cell survival. Dysregulation of these receptors has been implicated in various diseases, including cancer, autoimmune disorders, and inflammatory conditions.
The AB-753 antibody specifically targets these receptors, allowing for the detection and analysis of their expression and activity in a variety of cell types.By using the MERTK & TYRO3 Polyclonal Antibody (AB-753), researchers can further explore the roles of these receptors in immunology and cancer research. Understanding the molecular mechanisms of MERTK and TYRO3 can provide insights into potential therapeutic targets for manipulating immune responses and disease progression.
| Antibody Name: | MERTK/TYRO3 (Ab-753) Antibody (PACO21647) |
| Antibody SKU: | PACO21647 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from Internal of human MERTK. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from 3T3 cells (Lane 2), using MER (Ab-753) antiobdy. The lane on the left is treated with synthesized peptide. |
| Background: | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. |
| Synonyms: | c-mer; c-mer proto-oncogene tyrosine kinase; MER; MER receptor tyrosine kinase; MERTK |
| UniProt Protein Function: | Mer: a proto-oncogene receptor tyrosine-protein kinase of the Axl family. Binds several ligands including LGALS3, Tubby, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3 |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); EC 2.7.10.1; Oncoprotein; Kinase, protein; TK group; Axl family Chromosomal Location of Human Ortholog: 2q14.1 Cellular Component: extracellular space; photoreceptor outer segment; integral to plasma membrane; cytoplasm; plasma membrane Molecular Function:protein binding; transmembrane receptor protein tyrosine kinase activity; ATP binding Biological Process: platelet activation; negative regulation of lymphocyte activation; peptidyl-tyrosine phosphorylation; vagina development; protein amino acid phosphorylation; phagocytosis; cell surface receptor linked signal transduction; cell-cell signaling; retina development in camera-type eye; natural killer cell differentiation; positive regulation of phagocytosis; protein kinase B signaling cascade; spermatogenesis; blood coagulation; leukocyte migration; apoptotic cell clearance; secretion by cell Disease: Retinitis Pigmentosa 38 |
| NCBI Summary: | This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q12866 |
| NCBI GenInfo Identifier: | 160332297 |
| NCBI Gene ID: | 10461 |
| NCBI Accession: | Q12866.2 |
| UniProt Secondary Accession: | Q12866,Q9HBB4, |
| UniProt Related Accession: | Q12866 |
| Molecular Weight: | 999 |
| NCBI Full Name: | Tyrosine-protein kinase Mer |
| NCBI Synonym Full Names: | MER proto-oncogene, tyrosine kinase |
| NCBI Official Symbol: | MERTKÂ Â |
| NCBI Official Synonym Symbols: | MER; RP38; c-Eyk; c-mer; Tyro12Â Â |
| NCBI Protein Information: | tyrosine-protein kinase Mer; STK kinase; proto-oncogene c-Mer; MER receptor tyrosine kinase; receptor tyrosine kinase MerTK; c-mer proto-oncogene tyrosine kinase |
| UniProt Protein Name: | Tyrosine-protein kinase Mer |
| UniProt Synonym Protein Names: | Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK |
| Protein Family: | Tyrosine-protein kinase |
| UniProt Gene Name: | MERTKÂ Â |
| UniProt Entry Name: | MERTK_HUMAN |
| Antibodies |
| Phospho-MERTK/TYRO3 (Y749/681) Antibody (PACO02319) |
| MERTK/TYRO3 Antibody (PACO02320) |
| MERTK/TYRO3 Antibody (PACO06637) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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