The MERTK Rabbit Monoclonal Antibody is a valuable tool for researchers studying MERTK, a protein involved in the regulation of immune responses and cell signaling pathways. This antibody, produced using rabbit monoclonal technology, is highly specific and sensitive for detecting MERTK in human samples. It has been validated for use in various applications, including Western blotting, immunohistochemistry, and flow cytometry.MERTK, also known as c-Mer proto-oncogene tyrosine kinase, plays a crucial role in the clearance of apoptotic cells and the regulation of immune tolerance. Dysregulation of MERTK signaling has been implicated in various diseases, including cancer, autoimmune disorders, and inflammatory conditions.
By targeting MERTK, researchers can gain insights into the mechanisms underlying these diseases, potentially leading to the development of novel therapeutic strategies.Overall, the MERTK Rabbit Monoclonal Antibody is a powerful tool for studying the function of MERTK in health and disease. Its high specificity and sensitivity make it suitable for a wide range of research applications, making it a valuable addition to any immunology or oncology research laboratory.
Product Name:
MERTK Rabbit Monoclonal Antibody
SKU:
CAB12294
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MERTK (Q12866).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
110kDa
Observed MW:
150-200kDa
This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).
Purification Method:
Affinity purification
Gene ID:
10461
Clone Number:
ARC0229
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of HepG2 cells, using MERTK Rabbit mAb (CAB12294) at 1：1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
