The MERTK Polyclonal Antibody (CAB5443) is a crucial tool for research on MERTK, a receptor tyrosine kinase involved in phagocytosis and immune regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the MERTK protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential resource for studies in immunology and cancer research.MERTK is a key player in the regulation of immune responses and the clearance of apoptotic cells, making it a promising target for investigation in diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions.
By uncovering the mechanisms by which MERTK influences immune function, researchers can advance the development of therapeutic strategies that manipulate these processes for the benefit of patients. The MERTK Polyclonal Antibody (CAB5443) is a valuable tool for gaining insights into the role of MERTK in health and disease, paving the way for innovative approaches to treatment and care.
Product Name:
MERTK Rabbit Polyclonal Antibody
SKU:
CAB5443
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 26-499 of human MERTK (NP_006334.2).
This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).
Purification Method:
Affinity purification
Gene ID:
10461
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse spleen, using MERTK Rabbit pAb (CAB5443) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
