Merlin Polyclonal Antibody (CAB22558)
- SKU:
- CAB22558
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
Product Name: | Merlin Polyclonal Antibody |
SKU: | CAB22558 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 347-595 of human Merlin. (NP_000259.1). |
Sequence: | EEAE RTRD ELER RLLQ MKEE ATMA NEAL MRSE ETAD LLAE KAQI TEEE AKLL AQKA AEAE QEMQ RIKA TAIR TEEE KRLM EQKV LEAE VLAL KMAE ESER RAKE ADQL KQDL QEAR EAER RAKQ KLLE IATK PTYP PMNP IPAP LPPD IPSF NLIG DSLS FDFK DTDM KRLS MEIE KEKV EYME KSKH LQEQ LNEL KTEI EALK LKER ETAL DILH NENS DRGG SSKH NTIK KLTL QSAK SRVA FFEE L |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:100 - 1:500 |
Synonyms: | ACN; SCH; BANF; merlin-1; Merlin |
Positive Sample: | Jurkat,MCF7,HeLa |
Conjugate: | Unconjugated |
Cellular Localization: | cortical actin cytoskeleton, cytoplasm, cytoskeleton, cytosol, early endosome, filopodium membrane, nucleolus, nucleus, perinuclear region of cytoplasm, plasma membrane, ruffle membrane |
Calculated MW: | 70kDa |
Observed MW: | 75kDa |
This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that link cytoskeletal components with proteins in the cell membrane. The encoded protein is involved in regulation of contact-dependent inhibition of cell proliferation and functions in cell-cell adhesion and transmembrane signaling. The encoded protein has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics, and proteins involved in regulating ion transport. Disruption of this protein's function has been implicated in tumorigenesis and metastasis. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities.
Purification Method: | Affinity purification |
Gene ID: | 4771 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |