MEOX2 Antibody (PACO53314)
- SKU:
- PACO53314
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
MEOX2 Antibody (PACO53314)
The MEOX2 Polyclonal Antibody (PAC05314) is a valuable tool for researchers studying the MEOX2 protein, which is involved in the regulation of cell differentiation and development. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to MEOX2, this antibody allows for the detection and analysis of this protein in various cell types, making it an excellent choice for studies in developmental biology and cancer research.MEOX2, also known as mesenchyme homeobox 2, plays a crucial role in controlling the process of mesenchymal cell differentiation, which is essential for the formation of various tissues and organs in the body.
Dysregulation of MEOX2 has been associated with developmental disorders and cancer, making it a promising target for further investigation in these areas. Understanding the function of MEOX2 is vital for uncovering its potential therapeutic implications in diseases related to aberrant cell growth and differentiation.
| Antibody Name: | MEOX2 Antibody (PACO53314) |
| Antibody SKU: | PACO53314 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Homeobox protein MOX-2 protein (94-193AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: RAW264.7 whole cell lysate. All lanes: MEOX2 antibody at 5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 34 kDa. Observed band size: 34 kDa. |
| Background: | Mesodermal transcription factor that plays a key role in somitogenesis and is required for sclerotome development (By similarity). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle. |
| Synonyms: | Homeobox protein MOX-2 (Growth arrest-specific homeobox) (Mesenchyme homeobox 2), MEOX2, GAX MOX2 |
| UniProt Protein Function: | MEOX2: Role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and sclerotomal differentiation. May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 7p22.1-p21.3 Cellular Component: cytoplasm; nucleus Molecular Function:protein binding; sequence-specific DNA binding; transcription factor activity Biological Process: blood circulation; multicellular organismal development; positive regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P50222 |
| NCBI GenInfo Identifier: | 93141286 |
| NCBI Gene ID: | 4223 |
| NCBI Accession: | P50222.2 |
| UniProt Secondary Accession: | P50222,O75263, Q9UPL6, B2R8I7, |
| UniProt Related Accession: | P50222 |
| Molecular Weight: | 33,594 Da |
| NCBI Full Name: | Homeobox protein MOX-2 |
| NCBI Synonym Full Names: | mesenchyme homeobox 2 |
| NCBI Official Symbol: | MEOX2Â Â |
| NCBI Official Synonym Symbols: | GAX; MOX2Â Â |
| NCBI Protein Information: | homeobox protein MOX-2 |
| UniProt Protein Name: | Homeobox protein MOX-2 |
| UniProt Synonym Protein Names: | Growth arrest-specific homeobox; Mesenchyme homeobox 2 |
| Protein Family: | Homeobox protein |
| UniProt Gene Name: | MEOX2Â Â |
| UniProt Entry Name: | MEOX2_HUMAN |
| Antibodies | ELISA Kits |
| MEOX2 Antibody (PACO06649) | MEOX2 Colorimetric Cell-Based ELISA |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
Related Products
MEOX2 Antibody (PACO21789)
MEOX2 Antibody (PACO06649)
MEOX2 Colorimetric Cell-Based ELISA
