MEOX1 Antibody (PACO44657)
- SKU:
- PACO44657
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
MEOX1 Antibody (PACO44657)
The MEOX1 Polyclonal Antibody (PAC044657) is a valuable tool for researchers studying MEOX1, a transcription factor known for its role in regulating gene expression during development and in various diseases. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in applications such as Western blotting.MEOX1, also known as GAX, plays a crucial role in embryonic development, particularly in the formation of the skeleton and muscles. It is also implicated in diseases such as cancer, where it can act as a tumor suppressor or promoter depending on the context.
The MEOX1 antibody allows for the detection and analysis of MEOX1 protein levels in different cell types, providing insights into its function and potential therapeutic relevance in various conditions.Researchers interested in understanding the molecular mechanisms underlying development, disease, and therapeutic targets related to MEOX1 will find this antibody to be a valuable tool in their studies. Its specificity and reliability make it a trusted reagent for investigating the role of MEOX1 in both normal physiology and pathological conditions.
| Antibody Name: | MEOX1 Antibody (PACO44657) |
| Antibody SKU: | PACO44657 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Homeobox protein MOX-1 protein (1-254AA) |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO44657 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human gastric cancer using PACO44657 at dilution of 1:100. |
| Background: | Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints. Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome. |
| Synonyms: | Homeobox protein MOX-1 (Mesenchyme homeobox 1), MEOX1, MOX1 |
| UniProt Protein Function: | MEOX1: Role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and sclerotomal differentiation. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription factor Chromosomal Location of Human Ortholog: 17q21 Cellular Component: cytoplasm; nucleus Molecular Function:protein binding; sequence-specific DNA binding; transcription factor activity Biological Process: multicellular organismal development Disease: Klippel-feil Syndrome 2, Autosomal Recessive |
| NCBI Summary: | This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the molecular signaling network regulating somite development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P50221 |
| NCBI GenInfo Identifier: | 1709078 |
| NCBI Gene ID: | 4222 |
| NCBI Accession: | P50221.1 |
| UniProt Secondary Accession: | P50221,Q15069, A8K524, A8MWF9, |
| UniProt Related Accession: | P50221 |
| Molecular Weight: | 15,628 Da |
| NCBI Full Name: | Homeobox protein MOX-1 |
| NCBI Synonym Full Names: | mesenchyme homeobox 1 |
| NCBI Official Symbol: | MEOX1Â Â |
| NCBI Official Synonym Symbols: | KFS2; MOX1Â Â |
| NCBI Protein Information: | homeobox protein MOX-1 |
| UniProt Protein Name: | Homeobox protein MOX-1 |
| UniProt Synonym Protein Names: | Mesenchyme homeobox 1 |
| Protein Family: | Homeobox protein |
| UniProt Gene Name: | MEOX1Â Â |
| UniProt Entry Name: | MEOX1_HUMAN |
| Antibodies |
| Anti-MEOX1 Antibody (CAB7332) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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