The Melanophilin Polyclonal Antibody (CAB6656) is a valuable tool for research involving Melanophilin, a protein involved in regulating intracellular transport and membrane trafficking in melanocytes. This antibody, produced in rabbits, is highly specific to human samples and is validated for Western blot applications. By targeting the Melanophilin protein, this antibody enables accurate detection and analysis in various cell types, making it an essential tool for studies in cell biology and melanosome biology.Melanophilin plays a crucial role in the biogenesis of melanosomes, which are specialized organelles responsible for melanin synthesis and distribution in melanocytes.
Dysregulation of Melanophilin has been linked to various pigmentation disorders and melanoma, underscoring its importance in melanocyte function. Research into Melanophilin function is essential for understanding the molecular mechanisms underlying pigmentation processes and melanocyte biology.Overall, the Melanophilin Polyclonal Antibody (CAB6656) is a valuable asset for researchers exploring the intricate pathways involved in pigment production and melanosome biology. Its specificity and sensitivity make it an indispensable tool for unraveling the complexities of melanocyte function and developing targeted therapies for pigment-related disorders.
Product Name:
MLPH Rabbit Polyclonal Antibody
SKU:
CAB6656
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 301-600 of human MLPH (NP_077006.1).
This gene encodes a member of the exophilin subfamily of Rab effector proteins. The protein forms a ternary complex with the small Ras-related GTPase Rab27A in its GTP-bound form and the motor protein myosin Va. A similar protein complex in mouse functions to tether pigment-producing organelles called melanosomes to the actin cytoskeleton in melanocytes, and is required for visible pigmentation in the hair and skin. A mutation in this gene results in Griscelli syndrome type 3, which is characterized by a silver-gray hair color and abnormal pigment distribution in the hair shaft. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
79083
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of Mouse stomach, using MLPH antibody (CAB6656) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
