The MEK7 Polyclonal Antibody is a valuable tool for researchers studying the MEK7 protein, a critical component of the MAPK signaling pathway involved in cell growth, proliferation, and differentiation. This antibody, produced in rabbits, exhibits high specificity and sensitivity to human samples, making it optimal for use in Western blot applications. By targeting the MEK7 protein, this antibody allows for the detection and analysis of MEK7 expression levels in a variety of cell types, making it ideal for investigations in cell biology and cancer research.
MEK7 is a key player in the MAPK signaling cascade, which is crucial for regulating cellular responses to various stimuli, including growth factors, stress signals, and cytokines. Dysregulation of this pathway is commonly associated with diseases such as cancer, making MEK7 a promising target for therapeutic intervention. By understanding the role of MEK7 in cell signaling, researchers can gain insights into potential therapeutic strategies for targeting aberrant MAPK activity in cancer and other diseases.
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
5609
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of Rat skeletal muscle, using MEK7 antibody (CAB23058) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
