The Meikin Antibody (PAC047846) is a polyclonal antibody designed for research involving CD300A, a cell surface molecule known for its role in immune regulation, specifically inhibiting immune responses. This antibody, raised in rabbits, is highly reactive with human samples and validated for Western blot applications. It binds to the CD300A protein, facilitating detection and analysis in various cell types, making it an excellent tool for studies in immunology and cancer research.
CD300A, also referred to as an immune inhibitory receptor, plays a crucial role in maintaining immune homeostasis by regulating inflammation and suppressing allergic reactions. Its involvement in immune response modulation makes it a valuable target for researching diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. Understanding the function of CD300A is essential for developing therapies that manipulate immune function in these disease contexts.
Antibody Name:
MEIKIN Antibody (PACO47846)
Antibody SKU:
PACO47846
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Meiosis-specific kinetochore protein (18-91AA)
Immunohistochemistry of paraffin-embedded human placenta tissue using PACO47846 at dilution of 1:100.
Background:
Key regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage. Acts by facilitating kinetochore mono-orientation during meiosis I, when kinetochores on sister chromosomes face the same direction and are thus captured and pulled by spindle fibers from the same pole. Also required to prevent cleavage of cohesin at centromeres during meiosis I, possibly by acting as a regulator of the shugoshin-dependent protection pathway. Acts in collaboration with PLK1: required for PLK1 enrichment to kinetochores. Not required during meiosis II or mitosis.
Synonyms:
Meiosis-specific kinetochore protein, MEIKIN
UniProt Protein Function:
MEIKIN: Key regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase- mediated cleavage. Acts by facilitating kinetochore mono- orientation during meiosis I, when kinetochores on sister chromosomes face the same direction and are thus captured and pulled by spindle fibers from the same pole. Also required to prevent cleavage of cohesin at centromeres during meiosis I, possibly by acting as a regulator of the shugoshin-dependent protection pathway. Acts in collaboration with PLK1: required for PLK1 enrichemnt to kinetochores. Not required during meiosis II or mitosis. {ECO:0000250|UniProtKB:Q5F2C3}. Interacts with CENPC. Interacts with PLK1; required for recruitment of PLK1 at kinetochores. {ECO:0000250|UniProtKB:Q5F2C3}Chromosomal Location of Human Ortholog: 5q31.1Cellular Component: condensed nuclear chromosome, pericentric regionBiological Process: female meiosis chromosome segregation; homologous chromosome segregation; male meiosis chromosome segregation; meiotic sister chromatid cohesion, centromeric
