The MEGF10 Polyclonal Antibody (CAB10508) is a valuable tool for researchers studying MEGF10, a protein known to play a role in cell adhesion and phagocytosis. This antibody, raised in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the MEGF10 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it ideal for studies in cellular biology and neuroscience.
MEGF10 is a key player in various cellular processes, including cell engulfment and clearance of apoptotic cells, as well as neuronal development and synaptic plasticity. Its functions make it an important target for research into neurodegenerative diseases, developmental disorders, and immune system regulation. Understanding the role of MEGF10 can provide valuable insights into these conditions and aid in the development of therapeutic strategies targeting this protein.
Product Name:
MEGF10 Rabbit Polyclonal Antibody
SKU:
CAB10508
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 26-160 of human MEGF10 (NP_115822.1).
Basolateral cell membrane, Cell membrane, Cell projection, Single-pass type I membrane protein, phagocytic cup.
Calculated MW:
122kDa
Observed MW:
130kDa
This gene encodes a member of the multiple epidermal growth factor-like domains protein family. The encoded protein plays a role in cell adhesion, motility and proliferation, and is a critical mediator of apoptotic cell phagocytosis as well as amyloid-beta peptide uptake in the brain. Expression of this gene may be associated with schizophrenia, and mutations in this gene are a cause of early-onset myopathy, areflexia, respiratory distress, and dysphagia (EMARDD) as well as congenital myopathy with minicores. Alternatively spliced transcript variants have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
84466
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of U-251 MG, using MEGF10 Rabbit pAb (CAB10508) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
