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MEF2D (Phospho-Ser444) Transcription Factor Activity Assay

SKU:
TFAB00055
Product Type:
ELISA Kit
ELISA Type:
Transcription Factor Assay
Analytes:
MEF2D (Phospho-Ser444)
Reactivity:
Human
Mouse
Rat
€599
Frequently bought together:

Description

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MEF2D (Phospho-Ser444)Transcription Factor Activity Assay

The MEF2D Phospho-Ser444 Transcription Factor Activity Assay offered by Assay Genie is a powerful tool for researchers studying transcription factor activity. This assay specifically detects phosphorylation of MEF2D at Ser444, providing valuable insights into the regulation of transcriptional activity.MEF2D is a key transcription factor involved in various cellular processes, including differentiation, proliferation, and survival. Phosphorylation at Ser444 is known to affect the activity of MEF2D, making it a critical site for studying its function.With high sensitivity and specificity, this assay delivers accurate and reproducible results, making it ideal for a wide range of research applications.

By understanding the activity of MEF2D and its phosphorylation status, researchers can gain valuable insights into gene regulation and potentially develop new therapies for diseases such as cancer, cardiovascular diseases, and neurodegenerative disorders.Overall, the MEF2D Phospho-Ser444 Transcription Factor Activity Assay is a valuable tool for researchers looking to advance their understanding of transcription factor activity and its role in various physiological and pathological processes.

Product Name:MEF2D (Phospho-Ser444) Transcription Factor Activity Assay
Product Code:TFAB00055
Target:MEF2D (Phospho-Ser444)
Reactivity:Human, Mouse, Rat
Sample Types:Nuclear or cell lysates

The Assay Genie MEF2D (Phospho-Ser444) transcription factor activity assay allows for the detection and qualitative analysis of MEF2D (Phospho-Ser444) active transcription factors in eukaryotic nuclear or cell lysates.

Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.

Assay Time:4.5 hours
Detection Method:Colorimetric 450 nm
Size:12 x 8-Well Microstrips
Storage:4°C for 6 months
UniProt Protein Function:MEF2D: transcription factor which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. May be involved in muscle-specific and/or growth factor-related transcription. Six splice-variant isoforms have been described.
UniProt Protein Details:

Protein type:DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 1q12-q23

Cellular Component: cytoplasm; intracellular membrane-bound organelle; nucleoplasm; nucleus

Molecular Function:histone deacetylase binding; protein binding; protein heterodimerization activity; protein homodimerization activity; transcription activator binding; transcription factor activity

Biological Process: adult heart development; apoptosis; chondrocyte differentiation; endochondral ossification; muscle development; nervous system development; osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter

NCBI Summary:This gene is a member of the myocyte-specific enhancer factor 2 (MEF2) family of transcription factors. Members of this family are involved in control of muscle and neuronal cell differentiation and development, and are regulated by class II histone deacetylases. Fusions of the encoded protein with Deleted in Azoospermia-Associated Protein 1 (DAZAP1) due to a translocation have been found in an acute lymphoblastic leukemia cell line, suggesting a role in leukemogenesis. The encoded protein may also be involved in Parkinson disease and myotonic dystrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
UniProt Code:Q14814
NCBI GenInfo Identifier:2500876
NCBI Gene ID:4209
NCBI Accession:Q14814.1
UniProt Secondary Accession:Q14814,Q14815, Q5T9U5, Q5T9U6, D3DVC0,
UniProt Related Accession:Q14814
Molecular Weight:49,856 Da
NCBI Full Name:Myocyte-specific enhancer factor 2D
NCBI Synonym Full Names:myocyte enhancer factor 2D
NCBI Official Symbol:MEF2D  
NCBI Protein Information:myocyte-specific enhancer factor 2D
UniProt Protein Name:Myocyte-specific enhancer factor 2D
Protein Family:Myocyte-specific enhancer factor
UniProt Gene Name:MEF2D  
UniProt Entry Name:MEF2D_HUMAN
Antibodies
Anti-MEF2D Antibody (CAB16398)
Phospho-MEF2D (S444) Antibody (PACO02899)
MEF2D Antibody (PACO04319)
MEF2D Antibody (PACO50478)
MEF2D Antibody, HRP conjugated (PACO50479)

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