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MEF2A (Phospho-Thr312) Transcription Factor Activity Assay

SKU:
TFAB00052
Product Type:
ELISA Kit
ELISA Type:
Transcription Factor Assay
Analytes:
MEF2A (Phospho-Thr312)
Reactivity:
Human
Mouse
Rat
€599
Frequently bought together:

Description

system_update_altDatasheet

MEF2A (Phospho-Thr312)Transcription Factor Activity Assay

The MEF2A Phospho Thr312 Transcription Factor Activity Assay is a highly sensitive and specific kit designed for detecting MEF2A phosphorylation at Thr312 in various samples such as cell lysates and tissue extracts. This assay provides accurate and reproducible results, making it suitable for a wide range of research applications.MEF2A is a key transcription factor that plays a crucial role in regulating gene expression involved in various cellular processes, including cell differentiation, proliferation, and apoptosis. Phosphorylation of MEF2A at Thr312 is essential for its transcriptional activity and plays a critical role in cell signaling pathways.

Understanding the activity of MEF2A at the molecular level is important for studying its role in different biological processes and its implications in various diseases such as cardiovascular disorders, muscular dystrophy, and neurodegenerative diseases. The MEF2A Phospho Thr312 Transcription Factor Activity Assay provides researchers with a valuable tool for investigating MEF2A function and its potential as a therapeutic target.

Product Name:MEF2A (Phospho-Thr312) Transcription Factor Activity Assay
Product Code:TFAB00052
Target:MEF2A (Phospho-Thr312)
Synonyms:Serum response factor-like protein 1
Reactivity:Human, Mouse, Rat
Sample Types:Nuclear or cell lysates

The Assay Genie MEF2A (Phospho-Thr312) transcription factor activity assay allows for the detection and qualitative analysis of MEF2A (Phospho-Thr312) active transcription factors in eukaryotic nuclear or cell lysates.

Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.

Assay Time:4.5 hours
Detection Method:Colorimetric 450 nm
Size:12 x 8-Well Microstrips
Storage:4°C for 6 months
UniProt Protein Function:MEF2A: a myocyte-specific enhancing transcription factor which binds specifically to the MEF2 element present in the regulatory regions of many, if not all, muscle-specific genes. A member of the MADS gene family that also includes several homeotic genes and other transcription factors, all of which share a conserved DNA-binding domain. Five alternatively spliced isoforms have been reported.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 15q26

Cellular Component: cytoplasm; nuclear chromatin; nucleoplasm; nucleus; transcription factor complex

Molecular Function:chromatin binding; histone acetyltransferase binding; histone deacetylase binding; protein binding; protein heterodimerization activity; protein kinase binding; RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding; SMAD binding; transcription activator binding; transcription factor activity

Biological Process: apoptosis; dendrite morphogenesis; heart development; innate immune response; MAPKKK cascade; mitochondrial genome maintenance; mitochondrion distribution; muscle cell differentiation; muscle development; MyD88-dependent toll-like receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; nerve growth factor receptor signaling pathway; positive regulation of muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; stress-activated MAPK cascade; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway; transcription from RNA polymerase II promoter; transcription, DNA-dependent; ventricular cardiac myofibril development

Disease: Coronary Artery Disease, Autosomal Dominant, 1

NCBI Summary:The protein encoded by this gene is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]
UniProt Code:Q02078
NCBI GenInfo Identifier:1170908
NCBI Gene ID:4205
NCBI Accession:Q02078.1
UniProt Secondary Accession:Q02078,O43814, Q14223, Q14224, Q59GX4, Q7Z6C9, Q96D14 B4DFQ7, F6XG23,
UniProt Related Accession:Q02078
Molecular Weight:45,570 Da
NCBI Full Name:Myocyte-specific enhancer factor 2A
NCBI Synonym Full Names:myocyte enhancer factor 2A
NCBI Official Symbol:MEF2A  
NCBI Official Synonym Symbols:mef2; ADCAD1; RSRFC4; RSRFC9  
NCBI Protein Information:myocyte-specific enhancer factor 2A
UniProt Protein Name:Myocyte-specific enhancer factor 2A
UniProt Synonym Protein Names:Serum response factor-like protein 1
Protein Family:Myocyte-specific enhancer factor
UniProt Gene Name:MEF2A  
UniProt Entry Name:MEF2A_HUMAN
AntibodiesELISA Kits
Anti-MEF2A Antibody (CAB12059)MEF2A (Phospho-Thr312) Colorimetric Cell-Based ELISA Kit
Anti-MEF2A Antibody (CAB7911)MEF2A (Phospho-Thr319) Colorimetric Cell-Based ELISA Kit
Phospho-MEF2A (S408) Antibody (PACO00319)MEF2A (Phospho-Ser408) Transcription Factor Activity Assay
MEF2A Antibody (PACO01055)MEF2A Transcription Factor Activity Assay
MEF2A Antibody (PACO02897)

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