The MED37A Polyclonal Antibody (PACO62115) is a valuable tool for researchers studying the MED37A protein and its role in cellular function. This antibody, developed using rabbits as the host species, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the MED37A protein, this antibody allows for easy detection and analysis in a variety of cell types, making it an ideal choice for studies in cell biology and molecular research.The MED37A protein is a key player in gene regulation and transcriptional activation processes, making it a crucial target for investigation in various biological pathways.
Its involvement in cellular functions such as RNA polymerase II transcription and chromatin remodeling highlights its importance in understanding gene expression mechanisms. Research on MED37A may provide insights into diseases related to gene dysregulation, developmental disorders, and certain types of cancer, making this antibody a valuable tool for advancing our knowledge in these areas.
Antibody Name:
MED37A Antibody (PACO62115)
Antibody SKU:
PACO62115
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:2000
Species Reactivity:
Arabidopsis thaliana
Immunogen:
Recombinant Arabidopsis thaliana Mediator of RNA polymerase II transcription subunit 37a protein (28-669AA)
Western Blot. Positive WB detected in: Arabidopsis thaliana leaf tissue. All lanes: MED37A antibody at 1:1000. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 74 kDa. Observed band size: 74 kDa.
Background:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.
Synonyms:
Mediator of RNA polymerase II transcription subunit 37a (Heat shock 70 kDa protein 11) (Heat shock protein 70-11) (AtHsp70-11) (Luminal-binding protein 1) (AtBP1) (BiP1), MED37A, BIP1 HSP70-11 MED37_5
UniProt Protein Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.
UniProt Protein Details:
NCBI Summary:
Encodes the luminal binding protein BiP, an ER-localized member of the HSP70 family. BiP is composed of an N-terminal ATP binding domain and a C-terminal domain that binds to hydrophobic patches on improperly/incompletely folded proteins in an ATP-dependent manner. Involved in polar nuclei fusion during proliferation of endosperm nuclei.
