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MED26 Antibody (PACO10443)

SKU:
PACO10443
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€459
Frequently bought together:

Description

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MED26 Antibody (PACO10443)

The MED26 Antibody (PAC010443) is a vital tool for researchers studying the MED26 protein, a key component of the Mediator complex involved in transcription regulation. This polyclonal antibody, produced in rabbits, shows high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the MED26 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an excellent choice for studies in molecular biology and gene expression research.

MED26 plays a crucial role in gene transcription regulation, serving as a bridge between transcription factors and the RNA polymerase II complex. Its importance in controlling gene expression makes it a valuable target for research into various diseases, including cancer, developmental disorders, and metabolic conditions. Understanding the function of MED26 is essential for unraveling the mechanisms underlying these diseases and developing targeted therapies to combat them.

Antibody Name:MED26 Antibody (PACO10443)
Antibody SKU:PACO10443
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:
Species Reactivity:Human, Mouse, Rat
Immunogen:Human MED26
Form:Liquid
Storage Buffer:PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method:Antigen Affinity purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:mediator complex subunit 26;MED26;CRSP7;CRSP70 ;ARC70;
UniProt Protein Function:MED26: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Belongs to the Mediator complex subunit 26 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 19p13.11

Cellular Component: nucleoplasm; Srb-mediator complex

Molecular Function:protein binding; transcription coactivator activity

Biological Process: regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter

NCBI Summary:The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [provided by RefSeq, Jul 2008]
UniProt Code:O95402
NCBI GenInfo Identifier:158931130
NCBI Gene ID:9441
NCBI Accession:O95402.2
UniProt Secondary Accession:O95402,Q0VGB6, A1A4S3,
UniProt Related Accession:O95402
Molecular Weight:10,359 Da
NCBI Full Name:Mediator of RNA polymerase II transcription subunit 26
NCBI Synonym Full Names:mediator complex subunit 26
NCBI Official Symbol:MED26  
NCBI Official Synonym Symbols:CRSP7; CRSP70  
NCBI Protein Information:mediator of RNA polymerase II transcription subunit 26
UniProt Protein Name:Mediator of RNA polymerase II transcription subunit 26
UniProt Synonym Protein Names:Activator-recruited cofactor 70 kDa component; ARC70; Cofactor required for Sp1 transcriptional activation subunit 7; CRSP complex subunit 7; Mediator complex subunit 26; Transcriptional coactivator CRSP70
Protein Family:Mediator of RNA polymerase II transcription
UniProt Gene Name:MED26  
UniProt Entry Name:MED26_HUMAN

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