MED26 Antibody (PACO03180)
- SKU:
- PACO03180
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
MED26 Antibody (PACO03180)
The MED26 Polyclonal Antibody (PACO03180) is a valuable tool for researchers studying the MED26 protein, an essential component of the Mediator complex involved in transcriptional regulation. This antibody, developed in rabbits, is highly specific for human samples and has been validated for use in Western blot applications.MED26 is a key player in gene expression control, playing a crucial role in various cellular processes such as cell growth, differentiation, and development. Its interaction with transcription factors and RNA polymerase II makes it a promising target for studies in molecular biology and cancer research.
By using the MED26 Polyclonal Antibody, researchers can effectively detect and analyze the MED26 protein in different cell types, providing insights into its function and potential implications in disease. This antibody is a valuable tool for advancing our understanding of gene regulation mechanisms and identifying new therapeutic targets for various disorders.
| Antibody Name: | MED26 Antibody |
| Antibody SKU: | PACO03180 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | WB:1:500-1:2000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | synthesized peptide derived from the N-terminal region of human CRSP70. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | MED26; ARC70; CRSP7; Mediator of RNA polymerase II transcription subunit 26; Activator-recruited cofactor 70 kDa component; ARC70; Cofactor required for Sp1 transcriptional activation subunit 7; CRSP complex subunit 7; Mediator complex subu |
| UniProt Protein Function: | MED26: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Belongs to the Mediator complex subunit 26 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 19p13.11 Cellular Component: nucleoplasm; Srb-mediator complex Molecular Function:protein binding; transcription coactivator activity Biological Process: regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter |
| NCBI Summary: | The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O95402 |
| NCBI GenInfo Identifier: | 158931130 |
| NCBI Gene ID: | 9441 |
| NCBI Accession: | O95402.2 |
| UniProt Secondary Accession: | O95402,Q0VGB6, A1A4S3, |
| UniProt Related Accession: | O95402 |
| Molecular Weight: | 10,359 Da |
| NCBI Full Name: | Mediator of RNA polymerase II transcription subunit 26 |
| NCBI Synonym Full Names: | mediator complex subunit 26 |
| NCBI Official Symbol: | MED26Â Â |
| NCBI Official Synonym Symbols: | CRSP7; CRSP70Â Â |
| NCBI Protein Information: | mediator of RNA polymerase II transcription subunit 26 |
| UniProt Protein Name: | Mediator of RNA polymerase II transcription subunit 26 |
| UniProt Synonym Protein Names: | Activator-recruited cofactor 70 kDa component; ARC70; Cofactor required for Sp1 transcriptional activation subunit 7; CRSP complex subunit 7; Mediator complex subunit 26; Transcriptional coactivator CRSP70 |
| Protein Family: | Mediator of RNA polymerase II transcription |
| UniProt Gene Name: | MED26Â Â |
| UniProt Entry Name: | MED26_HUMAN |
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