The MED24 Polyclonal Antibody (CAB8059) is a valuable tool for researchers studying MED24, a critical player in gene transcription regulation. This antibody, generated in rabbits, is highly specific to human samples and has been extensively validated for use in Western blot applications. By binding to the MED24 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential component for studies in molecular biology and cancer research.MED24, also known as mediator of RNA polymerase II transcription subunit 24, is involved in multiple cellular processes, including gene expression, cell proliferation, and DNA repair.
Its role in transcriptional regulation makes it a pivotal target for investigations into cancer development, as dysregulation of gene expression is commonly observed in oncogenesis. Understanding the function of MED24 is crucial for uncovering novel therapeutic targets and mechanisms underlying tumorigenesis, paving the way for advancements in cancer treatment strategies and personalized medicine.
Product Name:
MED24 Rabbit Polyclonal Antibody
SKU:
CAB8059
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human MED24 (NP_055630.2).
This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
9862
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using MED24 antibody (CAB8059) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 45s.
