| UniProt Protein Function: | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a subunit of the Mediator complex, a large complex of proteins that functions as a transcriptional coactivator for most RNA polymerase II-transcribed genes. The encoded protein is involved in early development of the heart and brain. Defects in this gene are a cause of transposition of the great arteries, dextro-looped (DTGA).[provided by RefSeq, Jul 2010] |
| UniProt Code: | Q71F56 |
| NCBI GenInfo Identifier: | 44771211 |
| NCBI Gene ID: | 23389 |
| NCBI Accession: | NP_056150.1 |
| UniProt Secondary Accession: | Q71F56,Q68DN4, Q9H8C0, Q9NSY9, Q9UFD8, Q9UPX5, A1L469 |
| UniProt Related Accession: | Q71F56 |
| Molecular Weight: | 242,602 Da |
| NCBI Full Name: | mediator of RNA polymerase II transcription subunit 13-like |
| NCBI Synonym Full Names: | mediator complex subunit 13 like |
| NCBI Official Symbol: | MED13LÂ Â |
| NCBI Official Synonym Symbols: | MRFACD; THRAP2; TRAP240L; PROSIT240Â Â |
| NCBI Protein Information: | mediator of RNA polymerase II transcription subunit 13-like |
| UniProt Protein Name: | Mediator of RNA polymerase II transcription subunit 13-like |
| UniProt Synonym Protein Names: | Mediator complex subunit 13-like; Thyroid hormone receptor-associated protein 2; Thyroid hormone receptor-associated protein complex 240 kDa component-like |
| Protein Family: | Mediator of RNA polymerase II transcription |
| UniProt Gene Name: | MED13LÂ Â |
| UniProt Entry Name: | |
