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MED13L Antibody (PACO03697)

SKU:
PACO03697
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€319

Description

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MED13L Antibody (PACO03697)

The MED13L Polyclonal Antibody (PACO3697) is a valuable tool for researchers studying the MED13L protein, a key regulator of gene transcription and development. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for use in Western blot applications. By binding to the MED13L protein, this antibody enables precise detection and analysis in a variety of cell types, facilitating research in fields such as genetics, developmental biology, and cancer research.

MED13L plays a crucial role in mediating gene expression and is essential for normal development and cellular function. Dysregulation of MED13L has been linked to various genetic disorders and developmental syndromes, underscoring its importance in human health and disease. By studying the function and regulation of MED13L, researchers can gain insights into the molecular mechanisms underlying these conditions and potentially identify new therapeutic targets.

Antibody Name:MED13L Antibody
Antibody SKU:PACO03697
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:Human, Mouse
Immunogen:synthesized peptide derived from the Internal region of human TRAP240.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:MED13L; KIAA1025; Mediator of RNA polymerase II transcription subunit 13-like; Mediator complex subunit 13-like; Thyroid hormone receptor-associated protein 2; Thyroid hormone receptor-associated protein complex 240 kDa component-like
UniProt Protein Function:Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway.
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene is a subunit of the Mediator complex, a large complex of proteins that functions as a transcriptional coactivator for most RNA polymerase II-transcribed genes. The encoded protein is involved in early development of the heart and brain. Defects in this gene are a cause of transposition of the great arteries, dextro-looped (DTGA).[provided by RefSeq, Jul 2010]
UniProt Code:Q71F56
NCBI GenInfo Identifier:44771211
NCBI Gene ID:23389
NCBI Accession:NP_056150.1
UniProt Secondary Accession:Q71F56,Q68DN4, Q9H8C0, Q9NSY9, Q9UFD8, Q9UPX5, A1L469
UniProt Related Accession:Q71F56
Molecular Weight:242,602 Da
NCBI Full Name:mediator of RNA polymerase II transcription subunit 13-like
NCBI Synonym Full Names:mediator complex subunit 13 like
NCBI Official Symbol:MED13L  
NCBI Official Synonym Symbols:MRFACD; THRAP2; TRAP240L; PROSIT240  
NCBI Protein Information:mediator of RNA polymerase II transcription subunit 13-like
UniProt Protein Name:Mediator of RNA polymerase II transcription subunit 13-like
UniProt Synonym Protein Names:Mediator complex subunit 13-like; Thyroid hormone receptor-associated protein 2; Thyroid hormone receptor-associated protein complex 240 kDa component-like
Protein Family:Mediator of RNA polymerase II transcription
UniProt Gene Name:MED13L  
UniProt Entry Name:

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