The MED12L Polyclonal Antibody (PACO10438) is a valuable tool for researchers studying the MED12L protein, a key factor in various cellular processes including gene regulation and RNA transcription. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By targeting the MED12L protein, this antibody allows for the detection and analysis of MED12L expression in a variety of cell types, making it ideal for investigations in molecular biology and developmental biology.
MED12L, a subunit of the Mediator complex, plays a crucial role in regulating gene expression and modulating transcriptional activity. Its involvement in various signaling pathways makes it a promising target for research into developmental disorders, cancer, and other diseases related to gene dysregulation. By studying the function of MED12L, researchers can gain insights into the mechanisms underlying these conditions and potentially identify new therapeutic targets for intervention.
MED12L: May be a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Belongs to the Mediator complex subunit 12 family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Transcription initiation complexChromosomal Location of Human Ortholog: 3q25.1Cellular Component: Srb-mediator complexMolecular Function: beta-catenin binding; transcription factor bindingBiological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is part of the Mediator complex, which is involved in transcriptional coactivation of nearly all RNA polymerase II-dependent genes. The Mediator complex links gene-specific transcriptional activators with the basal transcription machinery. [provided by RefSeq, May 2010]
