MECOM Antibody (PACO02896)
- SKU:
- PACO02896
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
MECOM Antibody (PACO02896)
The MECOM Antibody (PACO2896) is a valuable tool for researchers studying MECOM, a gene involved in various cellular processes including hematopoiesis, gene regulation, and cell differentiation. This polyclonal antibody, produced in rabbits, exhibits high reactivity with human samples and is suitable for use in immunofluorescence and immunohistochemistry applications.MECOM, also known as MDS1-EVI1 complex locus (ME), plays a critical role in the development and function of hematopoietic cells, making it a key target for investigation in research areas such as oncology, hematology, and stem cell biology.
Understanding the function and expression of MECOM is essential for unraveling its involvement in diseases like myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML).By utilizing the MECOM Antibody (PACO2896), researchers can gain valuable insights into the molecular mechanisms underlying MECOM-related disorders and potentially identify novel therapeutic targets for the treatment of these conditions. Don't miss out on the opportunity to enhance your research with this high-quality antibody.
| Antibody Name: | MECOM Antibody |
| Antibody SKU: | PACO02896 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300 |
| Species Reactivity: | Human |
| Immunogen: | synthesized peptide derived from the N-terminal region of human PRDM3. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | MECOM; MDS1; MDS1 and EVI1 complex locus protein MDS1; Myelodysplasia syndrome 1 protein; Myelodysplasia syndrome-associated protein 1 |
| UniProt Protein Function: | MDS1: A chromosomal aberration involving MDS1 is found in a form of acute myeloid leukemia (AML). Translocation t(3;21) with AML1. 6 isoforms of the human protein are produced by alternative promoter. |
| UniProt Protein Details: | Protein type:Transcription factor Chromosomal Location of Human Ortholog: 3q26.2 Cellular Component: cytoplasm; cytosol; Golgi apparatus; histone deacetylase complex; intracellular membrane-bound organelle; nuclear speck; nucleoplasm; nucleus Molecular Function:DNA binding; histone-lysine N-methyltransferase activity; protein binding; transcription factor activity Biological Process: negative regulation of JNK cascade; negative regulation of programmed cell death; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; regulation of cell cycle |
| NCBI Summary: | The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011] |
| UniProt Code: | Q13465 |
| NCBI GenInfo Identifier: | 24211973 |
| NCBI Gene ID: | 2122 |
| NCBI Accession: | Q13465.1 |
| UniProt Related Accession: | Q13465,Q03112 |
| Molecular Weight: | |
| NCBI Full Name: | MDS1 and EVI1 complex locus protein MDS1 |
| NCBI Synonym Full Names: | MDS1 and EVI1 complex locus |
| NCBI Official Symbol: | MECOMÂ Â |
| NCBI Official Synonym Symbols: | EVI1; MDS1; PRDM3; RUSAT2; MDS1-EVI1; AML1-EVI-1Â Â |
| NCBI Protein Information: | MDS1 and EVI1 complex locus protein EVI1 |
| UniProt Protein Name: | MDS1 and EVI1 complex locus protein MDS1 |
| UniProt Synonym Protein Names: | Myelodysplasia syndrome 1 protein; Myelodysplasia syndrome-associated protein 1 |
| Protein Family: | MDS1 and EVI1 complex locus protein |
| UniProt Gene Name: | MECOMÂ Â |
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