MECOM Antibody (PACO55906)
- SKU:
- PACO55906
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
MECOM Antibody (PACO55906)
The MECOM Antibody (PACO55906) is a polyclonal antibody designed for research involving MECOM, a transcription factor known to be involved in hematopoiesis and leukemia. The antibody, produced in rabbits, is highly specific to human samples and is validated for use in immunohistochemistry applications. It binds to the MECOM protein, enabling precise detection and analysis in various tissues and cell types, making it an invaluable tool for studies in oncology and hematological research.
MECOM, also known as EVI1, is a key player in the regulation of gene expression in hematopoietic stem cells and is implicated in the development of leukemia. Its role in hematopoiesis and leukemia pathogenesis makes it a promising target for therapeutic interventions in hematological malignancies. Understanding the function of MECOM is essential for developing targeted treatments that can effectively combat leukemia and other blood-related disorders.
| Antibody Name: | MECOM Antibody (PACO55906) |
| Antibody SKU: | PACO55906 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:500-1:1000 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Histone-lysine N-methyltransferase MECOM protein (534-632AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO55906 diluted at 1:500 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-β signaling. Involved in hematopoiesis. |
| Synonyms: | MDS1 and EVI1 complex locus protein (Ecotropic virus integration site 1 protein homolog) (EVI-1) (Myelodysplasia syndrome 1 protein) (Myelodysplasia syndrome-associated protein 1), MECOM, EVI1 |
| UniProt Protein Function: | Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. |
| NCBI Summary: | The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011] |
| UniProt Code: | Q03112 |
| NCBI GenInfo Identifier: | 145559472 |
| NCBI Gene ID: | 2122 |
| NCBI Accession: | Q03112.2 |
| UniProt Secondary Accession: | Q03112,Q16122, Q5HYI1, Q6MZS6, Q8NEI5, A1L4F3, A8KA00 B7Z8W7, B7ZLQ3, B7ZLQ4, C9JAK0, D3DNP7, |
| UniProt Related Accession: | Q13465,Q03112 |
| Molecular Weight: | 117,232 Da |
| NCBI Full Name: | MDS1 and EVI1 complex locus protein EVI1 |
| NCBI Synonym Full Names: | MDS1 and EVI1 complex locus |
| NCBI Official Symbol: | MECOMÂ Â |
| NCBI Official Synonym Symbols: | EVI1; MDS1; PRDM3; RUSAT2; MDS1-EVI1; AML1-EVI-1Â Â |
| NCBI Protein Information: | MDS1 and EVI1 complex locus protein EVI1 |
| UniProt Protein Name: | MDS1 and EVI1 complex locus protein EVI1 |
| UniProt Synonym Protein Names: | Ecotropic virus integration site 1 protein homolog; EVI-1 |
| Protein Family: | MDS1 and EVI1 complex locus protein |
| UniProt Gene Name: | MECOMÂ Â |
| UniProt Entry Name: | EVI1_HUMAN |
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