MDM2 Monoclonal Antibody (CAB23388)
- SKU:
- CAB23388
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Frequently bought together:
Description
Product Name: | MDM2 Monoclonal Antibody |
SKU: | CAB23388 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 101-200 of human MDM2 (NP_001354919.1). |
Sequence: | TMIY RNLV VVNQ QESS DSGT SVSE NRCH LEGG SDQK DLVQ ELQE EKPS SSHL VSRP STSS RRRA ISET EENS DELS GERQ RKRH KSDS ISLS FDES LALC |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:1000 - 1:5000 |
Synonyms: | HDMX; LSKB; hdm2; ACTFS; MDM2 |
Positive Sample: | U2OS+Nutlin 3a |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus, nucleolus, nucleoplasm. |
Calculated MW: | 11kDa/14kDa/24kDa/30kDa/33kDa/35kDa/48kDa/49kDa/55kDa |
Observed MW: | 90kDa |
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.
Purification Method: | Affinity purification |
Gene ID: | 4193 |
Clone Number: | ARC60296 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3. |