The MDM1 Polyclonal Antibody (PACO03029) is a valuable tool for researchers studying MDM1, a key protein involved in cell division and proliferation. This antibody, produced through the immunization of rabbits, is highly specific and reacts strongly with human samples, making it suitable for Western blot applications.MDM1, also known as MDMX or HDMX, plays a crucial role in regulating the activity of the tumor suppressor protein p53, making it a potential target for cancer research. By binding to MDM1, this antibody allows for the detection and analysis of the protein in various cell types, providing insights into its function and potential therapeutic implications.
Research on MDM1 is essential for understanding its role in tumorigenesis and developing targeted therapies for cancer treatment. The MDM1 Polyclonal Antibody is a reliable tool for investigating MDM1 function in both normal and diseased tissues, offering valuable insights into potential therapeutic strategies for cancer.
Antibody Name:
MDM1 Antibody
Antibody SKU:
PACO03029
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the C-terminal region of human MDM1.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
MDM1; Nuclear protein MDM1
UniProt Protein Function:
MDM1: a nuclear protein similar to the mouse double minute 1 protein. The mouse gene is located in double minute (DM) chromatin particles, is amplified in the mouse transformed 3T3 cell line, and the encoded protein is able to bind to p53. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]Protein type: Unknown functionChromosomal Location of Human Ortholog: 12q15Cellular Component: centriole; centrosome; nucleusMolecular Function: microtubule bindingBiological Process: negative regulation of centriole replication; retina development in camera-type eye
UniProt Protein Details:
NCBI Summary:
This gene encodes a nuclear protein similar to the mouse double minute 1 protein. The mouse gene is located in double minute (DM) chromatin particles, is amplified in the mouse transformed 3T3 cell line, and the encoded protein is able to bind to p53. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
