MDC1 Rabbit Polyclonal Antibody (CAB8358)
- SKU:
- CAB8358
- Product Type:
- Antibody
- Applications:
- WB
- IHC
- IF
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Cycle
Frequently bought together:
Description
Product Name: | MDC1 Rabbit Polyclonal Antibody |
SKU: | CAB8358 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human MDC1 (NP_055456.2). |
Sequence: | MEDT QAID WDVE EEEE TEQS SESL RCNV EPVG RLHI FSGA HGPE KDFP LHLG KNVV GRMP DCSV ALPF PSIS KQHA EIEI LAWD KAPI LRDC GSLN GTQI LRPP KVLS PGVS HRLR DQEL ILFA DLLC QYHR LDVS LPFV SRGP LTVE ETPR VQGE TQPQ RLLL AEDS EEEV DFLS ERRM VKKS RTTS SSVI VPES DEEG HSPV LGGL GPPF AFNL NSDT DVEE GQQP ATEE ASSA ARRG ATVE AKQS EAEV VTEI QLEK DQPL VKER DNDT KVKR GAGN GVVP AGVI LERS QPPG EDSD TDVD DDSR PPGR PAEV HLER AQPF GFID SDTD AEEE RIPA TPVV IPMK KR |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | NFBD1; MDC1 |
Positive Sample: | Jurkat,LO2 |
Conjugate: | Unconjugated |
Cellular Localization: | Chromosome, Nucleus. |
Calculated MW: | 227kDa |
Observed MW: | 270kDa |
The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.
Purification Method: | Affinity purification |
Gene ID: | 9656 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |