MDC1 Rabbit Polyclonal Antibody (CAB12714)
- SKU:
- CAB12714
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
Product Name: | MDC1 Rabbit Polyclonal Antibody |
SKU: | CAB12714 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MDC1 (NP_055456.2). |
Sequence: | MEDT QAID WDVE EEEE TEQS SESL RCNV EPVG RLHI FSGA HGPE KDFP LHLG KNVV GRMP DCSV ALPF PSIS KQHA EIEI LAWD KAPI LRDC GSLN GTQI |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | NFBD1; MDC1 |
Positive Sample: | Mouse testis |
Conjugate: | Unconjugated |
Cellular Localization: | Chromosome, Nucleus. |
Calculated MW: | 227kDa |
Observed MW: | 226kDa |
The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.
Purification Method: | Affinity purification |
Gene ID: | 9656 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |