The MCU Polyclonal Antibody (CABXXXXX) is a crucial tool for researchers studying the MCU protein, which plays a key role in mitochondrial calcium uptake. This antibody, raised in rabbits, is highly specific for MCU and is validated for use in multiple applications such as Western blot and immunofluorescence.The MCU protein is essential for maintaining calcium homeostasis in mitochondria, which is crucial for various cellular processes including energy production and cell death regulation. Dysregulation of MCU has been linked to various diseases including neurodegenerative disorders and cardiovascular diseases.
By using the MCU Polyclonal Antibody, researchers can accurately detect and analyze MCU protein levels in different cell types and tissues, enhancing their understanding of the protein's function and potential implications in disease pathology. This antibody is a valuable tool for studies in mitochondrial biology, cell signaling, and potential therapeutic targets related to MCU dysfunction.
Product Name:
MCU Polyclonal Antibody
SKU:
CAB21753
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 51-170 of human MCU (NP_612366.1).
Enables calcium channel activity; identical protein binding activity; and uniporter activity. Involved in several processes, including positive regulation of mitochondrial calcium ion concentration; positive regulation of mitochondrial fission; and positive regulation of neutrophil chemotaxis. Acts upstream of or within calcium import into the mitochondrion. Located in mitochondrial inner membrane. Is integral component of mitochondrial inner membrane. Part of uniplex complex.
Purification Method:
Affinity purification
Gene ID:
90550
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of Mouse spleen, using MCU Rabbit pAb (CAB21753) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
